The Utilization and Impact of Aromatase Inhibitor Therapy in Men With Elevated Estradiol Levels on Testosterone Therapy

Certain pharmaceutical products have an estrogen-blocking effect in males. While typically designed for females, they’re gaining in popularity among males — particularly those who wish to have children. Your gender identity may not align with how your body responds to this condition. Your doctor can better help you understand how your specific circumstances will translate into diagnosis, symptoms, and treatment. We use “male” and “female” in this article to reflect the terms that have been historically used to describe a person’s sex, and “men” and “women” when referring to gender. A person’s gender identity may be different from the sex they were assigned at birth.

General Information About Male Breast Cancer

The tissue of the prostate and the cardiovascular system are not made for such a high level. Estrogen acts in the nervous system and influences our neurotransmitters. Additionally, an individual’s health status and medical history can also affect what a man’s normal estrogen level will be. For the past 30 years, a slow decline of testosterone in men led toestrogen dominance.

Our secondary (which include safety) outcomes are to evaluate changes in body composition, bone health, and metabolic markers. Subjects included in the AI+WL group experienced a non-significant trend for higher weight loss, but a significantly higher reduction in total body fat mass compared to PBO+WL. Importantly, no significant differences in lean mass changes were observed. Weight loss-induced loss of muscle mass is always a concern when prescribing diet therapy, especially in the context of aging and hypogonadism, both of which are considered risk factors for sarcopenia (32, 33). In addition, studies on hypogonadal men have shown a correlation between changes in testosterone levels and changes in lean mass (36).

Using an Estrogen Blocker

• The body composition assessment was performed by dual-energy X-ray absorptiometry (DXA) (Hologic-Discovery; Enhanced Whole Body 11.2 software version; Hologic Inc, Bedford, MA; USA) at baseline, 3 and 6 months.
• Exemestane (Aromasin) is in a class of medications called aromatase inhibitors.
• Even though aromatase inhibitors have been used for many years, more time is still needed to assess the long-term risks of these drugs.
• Despite these benefits, aromatase inhibitors can cause significant side effects, including accelerated bone loss leading to osteoporosis.
• When estrogen becomes excessively high in a man’s standard, it will start opposing testosterone.

A sensitivity analysis only using LCMS measurements revealed similar results (Supplementary Table 3). This substance is found in the majority of cruciferous vegetables, including cauliflower, broccoli, cabbage, brussels sprouts, bok choy, and turnip greens. These substances facilitate the breakdown of estrogen into other metabolites. This cruciferous plant has many health https://acent.tech/an-overview-of-steroids-that-help-maintain-muscle-3/ benefits, including fertility improvements. It is known to have anti-estrogen potential by reducing the conversion of testosterone.

There are both pharmaceutical estrogen blockers and natural estrogen blockers. Men receiving exogenous TTH may experience side effects, including elevations in E2 levels, which may impact libido and cause gynecomastia. Our study evaluated men with TD in which a small subset had elevated E2 requiring intervention (AZ). Overall, we demonstrated a statistically significant reduction in E2 levels to normal physiologic levels with maintenance of T levels, but were unable to identify predictors for men most likely to respond to therapy. Several estrogen blocker medications used to treat the imbalance of testosterone to estrogen were initially developed for use in treating female breast cancer.

A small, controlled study demonstrated that anastrozole in a dose of 1 mg daily during 12 weeks will result in doubling of the mean bioavailable testosterone level in older men [36]. A more recent study also showed a moderate but significant effect of aromatase inhibition on estradiol and testosterone levels in older men [37]. Treatment with atamestane 100 mg once daily resulted in a 40% increase in total testosterone levels after 36 weeks. However, no beneficial effects were seen on muscle strength, body composition or quality-of-life scores.